Plasticity in Glioma Stem Cell Phenotype and Its Therapeutic Implication
نویسندگان
چکیده
منابع مشابه
Plasticity in Glioma Stem Cell Phenotype and Its Therapeutic Implication
The marked heterogeneity in glioblastoma (GBM) may be induced through dynamic differentiation and dedifferentiation process of glioma cells. The hypothesis that environmental stimuli induce these phenotypic changes, including dedifferentiation into the stem cell phenotype which contributes to the high invasiveness and resultant poor outcome in GBM patients, is recently being proven. In the proc...
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The connection between epithelial-mesenchymal (E-M) plasticity and cancer stem cell (CSC) properties has been paradigm-shifting, linking tumor cell invasion and metastasis with therapeutic recurrence. However, despite their importance, the molecular pathways involved in generating invasive, metastatic, and therapy-resistant CSCs remain poorly understood. The enrichment of cells with a mesenchym...
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ژورنال
عنوان ژورنال: Neurologia medico-chirurgica
سال: 2018
ISSN: 0470-8105,1349-8029
DOI: 10.2176/nmc.ra.2017-0089